Yoserfloxin

Yoserfloxin

Difloxacin 10 %

Composition: Each 1 ml yoserfloxin conatins;

Difloxacin hydrochloride 109.12 mg, equvelant to 100 mg Difloxacin base

Pharmacokinetics:

1. Yoserfloxin is Rapid and almost absorbed after oral administration.
2. Bioavailability of Yoserfloxin reach to 96.4 %.
3. The Peak of Yoserfloxin Plasma concentration achieved within 1-2 hours.
4. Yoserfloxin is stable in medicated water for 24 hours, so medicated water should be prepared daily.
5. Yoserfloxin is uniformly distributed in the tissue and plasma of poultry and turkey.

The biliary excretion is the predominant elimination route for yosrfloxin.

Yoserfloxin have a longer half-life than other fluoroquinolones, so staying in the body longer. It allows for once-daily application

Withdrawal time of Yoserfloxin in Chicken and turkeys Meat is 24 hours.

Pharmacodynamics

1. Yoserfloxin has a bactericidal action.
2. Yoserfloxin is a broad-spectrum antimicrobial, active against the most gram-negative and gram-positive poultry pathogens as (E. coli, Salmonella spp., Pasteurella  spp. Staphylococcus aureus, Klebsiella spp., and mycoplasma) 
3. Yoserfloxin showed low levels of resistance (5-6%) for E. coli, Salmonella spp. and Pasteurella multocida isolates.
4. Yoserfloxin of high safety margine; three fold therapeutic dose for two times daily, 10 days.

Indications of Yoserfloxin

1. Treatment of chronic respiratory disease (Mycoplasma gallisepticum, E. coli).
2. For Controlling airsacculitis (Mycoplasma meleagridis).
3. In case of infectious synovitis (Mycoplasma synoviae).
4. Used for prevention and control of colibacillosis and salmonellosis.
5. For control of fowl cholera caused by Pasteruella multocida.
6. For treatment of infectious coryza (Haemophilus paragallinarum).
7. In case of Staphylococcosis (Staphylococcus aureus).
8. 8. Recommended in treatment chlamydiosis (Chlamydia psittaci) in poultry

Dosage and administration

• In drinking water for 3-5 days.
• 5 mg Difloxin/ kg equivalent to; 0.5 ml Yoserfloxin /10 kg B.wt.